Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Suhaila M. Yaman

Department of Chemical Research and Development, Oncogen Pharma, Malaysia


  • Research Article   
    New Route for the synthesis of Bosutinib
    Author(s): Pawan Kumar*, Mursyidah Rahim, Suhaila M. Yaman and Sandeep Mhetre

    An improved and efficient synthesis route to bosutinib is reported. The initial route introduced by Pfizer, implemented Gould-Jacob reactions as key steps. In this protocol, the synthesis, isolation characterization of novel intermediates and their application in the alkylation step for the synthesis of bosutinib are briefly described, using an economic and practical procedure. Ultimately, we provide a new alternative of bosutinib synthesis route, through alkylation of alkali-intermediate with good yield... Read More»

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