Anjali Sharma

Department of Biotechnology, Meerut Institute of Engineering and Technology, Meerut 250005, India

Publications

• Research   
  Quantitative Structure-Activity Relationship and Molecular Modeling Studies on a series of constrained (L-)-S-adenosyl-L-homocysteine (SAH) analogues acting as DNA methyltransferase inhibitors.
  Author(s): Arshita Jindal, Anjali Sharma and Neeraj Agarwal*
  
  DNA methyltransferases catalyses the transfer of methyl group to DNA. However, in the current study, a series of DNA methyltransferase inhibitors and new compound with better efficacy were predicted. Hence quantitative structure activity relationship (QSAR) studies were done on the series of constrained (L-)-S-adenosyl-L-homocysteine (SAH) analogues acting as DNA methyltransferase inhibitors, and afterwards followed by molecular modelling which gives cross-validated result (r 2 cv) of 0.653 carried out by Leave one out (LOO) method, and predicted (r 2 pred.) is 0.600 with coefficient of correlation of (r) get by the multiple regression analysis is 0.934. Based on the model generated by the quantitative structure-activity relationship (QSAR) series of new compounds have been generated. Then these compounds were docked with the protein and ADME properties of each of the newly proposed c.. Read More»
  

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