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Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Chinedu Emmanuel Nnadi

Department of Science Laboratory Technology University of Nigeria, Nsukka, Nigeria

Publications

  • Research Article   
    BENZOTHIAZOLE DERIVATIVES AS A POTENTIAL ANTIMALARIA DRUG
    Author(s): Vivian Ifeoma Okonkwo, Chinedu Emmanuel Nnadi, Cosmas Chinweike Eze, Faith Elijah Temitope and Ebuka Leonard Onyeyilim*

    Plasmodium berghei is transmitted by Anopheles mosquitoes and it infects the liver after being injected into the bloodstream by a bite of an infected female mosquito. We have reported the synthesis of benzothiazole derivatives (compound 3a-b) by condensing 2-aminothiophenol with different aromatic aldehydes in polyethylene glycol-400 and the progress of the reaction was monitored using thin-layer chromatography, with dichloromethane and n-hexane used as a developing solvent in the ratio of 2:1. The synthesized compound was characterized by 13C-Nuclear Magnetic Resonance and 1H- Nuclear Magnetic Resonance. The acute toxicity of the synthesized compound was evaluated and found to be less toxic. The antimalarial activity of the compound was also studied in-vitro using albino mice and the result showed that the compound has significant antimalarial activity against Plasmodium berghei... Read More»
    DOI: 10.4172/0975-413X.15.4.54-63

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