Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Umar J Pandit

Department of Chemistry, Rare Earth and Electroanalytical Research Laboratory, Dr. Harisingh Gour (Central) University, Sagar, Madhya Pradesh 470003, India


  • Research Article   
    Electrochemical and Spectroscopic Evaluation on Interaction of Anticancer Drug Bicalutamide with DNA
    Author(s): Umar J Pandit, Gowhar A Naikoo, Gulzar A Khan, Sneha Wankar, Imran Khan, Raj KK and Limaye SN*

    Differential Pulse (DP) voltammetry, spectrophotometry, fluorescence emission spectroscopy and docking simulations were employed to investigate the interaction of an anticancer drug Bicalutamide (BIC) with CT-DNA (Calf thymus-DNA). At modified single walled carbon nanotube carbon paste (SWCNT-CP) electrode the anticancer drug BIC produced a well-defined cathodic reduction peak which decreased on addition of CT-DNA. On increasing concentrations of CT-DNA no shift of peak potential of BIC was observed, characteristic of Groove binding mode of interaction. A binding constant (K) of 2.13 × 106 M-1 was determined by DP voltammetric method. In addition, the interaction of BIC with CT-DNA was further examined by spectrophotometric and fluorescent emission techniques. Interestingly, the binding constants (K) obtained through spectrophotometric method and vol.. Read More»

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